Anti-JNK1 (1H8) Mouse antibody

Anti-JNK1 (1H8) Mouse antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

JNK1 (1H8) Mouse monoclonal antibody

WB, FC

Human, Mouse

Mouse IgG1

Antigen: Purified recombinant fragment of human MAPK8 expressed in E. Coli.

Monoclonal

Purified antibody in PBS with 0.05% sodium azide

Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Swiss-Prot Acc.P45983.The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.