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  • Anti-PERK Rabbit antibody

Anti-PERK Rabbit antibody

Cat.#: 169017

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Special Price 441.3 USD

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Product Information

  • Product Name
    Anti-PERK Rabbit antibody
  • Documents
  • Description
    PERK Rabbit monoclonal antibody
  • Tested applications
    WB
  • Species reactivity
    Human, Mouse, Rat
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant protein of human PERK
  • Clonality
    Monoclonal antibody
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    1:1000

  • Validations

    Western blot detection of PERK in K562,C6,3T3,Hela cell lysates using PERK Rabbit mAb(1:1000 diluted).Predicted band size:125kDa.Observed band size:140kDa.

    Western blot detection of PERK in K562,C6,3T3,Hela cell lysates using PERK Rabbit mAb(1:1000 diluted).Predicted band size:125kDa.Observed band size:140kDa.

  • Background
    Swiss-Prot Acc.Q9NZJ5.Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"