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  • Anti-Pellino 1 Rabbit antibody

Anti-Pellino 1 Rabbit antibody

Cat.#: 168905

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Special Price 441.3 USD

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Product Information

  • Product Name
    Anti-Pellino 1 Rabbit antibody
  • Documents
  • Description
    Pellino 1 Rabbit monoclonal antibody
  • Tested applications
    WB, ICC/IF, IP
  • Species reactivity
    Human, Mouse, Rat
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant protein of human Pellino 1
  • Clonality
    Monoclonal antibody
  • Formulation
    50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/1000

    ICC/IF: 1/20

    IP: 1/20

  • Validations

    Western blot detection of Pellino 1 in Rat Brain,Jurkat cell lysates using Pellino 1 Rabbit mAb(1:500 diluted).Predicted band size:46kDa.Observed band size:46kDa.

    Western blot detection of Pellino 1 in Rat Brain,Jurkat cell lysates using Pellino 1 Rabbit mAb(1:500 diluted).Predicted band size:46kDa.Observed band size:46kDa.

  • Background
    Swiss-Prot Acc.Q96FA3.E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609).
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"