-
Product Name
Anti-NTH1 Rabbit antibody
- Documents
-
Description
NTH1 Rabbit monoclonal antibody
-
Tested applications
WB, ICC/IF
-
Species reactivity
Human, Mouse, Rat
-
Alternative names
FAP3; NTH1; OCTS3; hNTH1 antibody
-
Isotype
Rabbit IgG
-
Preparation
Antigen: Recombinant protein of human NTH1
-
Clonality
Monoclonal
-
Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
-
Storage instructions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
-
Applications
WB: 1/1000
ICC/IF: 1/20
-
Validations
Western blot detection of NTH1 in K562,Hela cell lysates using NTH1 Rabbit mAb(1:1000 diluted).Predicted band size:34kDa.Observed band size:34kDa.
-
Background
Swiss-Prot Acc.P78549.Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"