Anti-NAALADL1 antibody

Anti-NAALADL1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit monoclonal to NAALADL1

IHC-P

Mouse NAALADL1
Has cross-reactivity in ELISA with Human NAALADL1

Gm964 antibody; I100 antibody; Naaladasel antibody; NAALADASEL antibody; Naaladl1 antibody; NAALADL1 antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Mouse NAALADL1 (rM NAALADL1; Q7M758; Pro29-Leu745).

Monoclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

N-acetylated-alpha-linked acidic dipeptidase-like protein, also known as NAALADL1, NAALADase L, and Ileal dipeptidylpeptidase, is a Single-pass type I I membrane protein and a member of the peptidase M28 family and M28B subfamily. NAALADase L is mainly expressed in the distal small intestine. It is also expressed in the spleen and testis and Weakly expressed in the brain, locating mainly to the brain stem, amygdala, thalamus and ventral striatum. NAALADase L is a chloride-activated, membrane bound, metallopeptidase that cleaves the endogenous neuropeptide N-acetyl-aspartyl-glutamate (NAAG). NAAG acts as a partial NMDA agonist as well as a full agonist at the presynaptic metabotropic glutamate receptor 3 (mGluR3), where it acts to reduce glutamate release. NAALADase L also exhibits a dipeptidyl-peptidase IV type activity. NAALADase inhibition may be a novel therapeutic approach to reduce or inhibit heightened aggressiveness, and possibly to treat aggressive behavior associated with psychiatric disorders.

• Stauch BL. 1989, Neurosci Lett. 100 (1-3): 295-300.
• Shneider BL. et al., 1997, J. Biol. Chem. 272: 31006-15.
• Pangalos MN. et al., 1999, J. Biol. Chem. 274: 8470-83.
• Thomas AG. et al., 1999, Brain Res. 843 (1-2): 48-52.