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Product Name
Anti-NAALADL1 antibody
- Documents
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Description
Rabbit polyclonal to NAALADL1
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Tested applications
ELISA, IHC-P
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Species reactivity
Mouse NAALADL1
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Alternative names
Gm964 antibody; I100 antibody; Naaladasel antibody; NAALADASEL antibody; Naaladl1 antibody; NAALADL1 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Mouse NAALADL1 (rM NAALADL1; Q7M758; Pro29-Leu745). NAALADL1 specific IgG was purified by Mouse NAALADL1 affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS with 5% trehalose
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse NAALADL1. The detection limit for Mouse NAALADL1 is 0.00975 ng/well.
IHC-P: 0.1-2 μg/mL
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Validations
NAALADL1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
Immunochemical staining of mouse NAALADL1 in mouse brain with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
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Background
N-acetylated-alpha-linked acidic dipeptidase-like protein, also known as NAALADL1, NAALADase L, and Ileal dipeptidylpeptidase, is a Single-pass type I I membrane protein and a member of the peptidase M28 family and M28B subfamily. NAALADase L is mainly expressed in the distal small intestine. It is also expressed in the spleen and testis and Weakly expressed in the brain, locating mainly to the brain stem, amygdala, thalamus and ventral striatum. NAALADase L is a chloride-activated, membrane bound, metallopeptidase that cleaves the endogenous neuropeptide N-acetyl-aspartyl-glutamate (NAAG). NAAG acts as a partial NMDA agonist as well as a full agonist at the presynaptic metabotropic glutamate receptor 3 (mGluR3), where it acts to reduce glutamate release. NAALADase L also exhibits a dipeptidyl-peptidase IV type activity. NAALADase inhibition may be a novel therapeutic approach to reduce or inhibit heightened aggressiveness, and possibly to treat aggressive behavior associated with psychiatric disorders.
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References
- Stauch BL. 1989, Neurosci Lett. 100 (1-3): 295-300.
- Shneider BL. et al., 1997, J. Biol. Chem. 272: 31006-15.
- Pangalos MN. et al., 1999, J. Biol. Chem. 274: 8470-83.
- Thomas AG. et al., 1999, Brain Res. 843 (1-2): 48-52.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"