Anti-MST1R antibody

Anti-MST1R antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Mouse MST1R

IHC-P

Mouse CD136/MST1R

RON antibody; PTK8 antibody; CD136 antibody; CDw136 antibody; Fv2 antibody; Ron antibody; STK antibody; Fv-2 antibody; PTK8 antibody; CD136 antibody; CDw136 antibody; Cd136 antibody; CD136 antibody; CDw136 antibody; CDw136 antibody; Fv2 antibody; Fv-2 antibody; Mst1r antibody; MST1R antibody; PTK8 antibody; PTK8 antibody; Ron antibody; RON antibody; STK antibody

Rabbit IgG

Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Mouse CD136/MST1R, and purified by antigen affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. As tyrosine kinase receptor comprised of an extra-cellular domain, MST1R protein contains the ligand binding pocket and an intracellular region where the kinase domain is located. MST1R signaling may be involved in the regulation of macrophage and T-lymphocyte activation in vivo during injury. This assessment of gene expression indicates the importance of genetic factors in contributing to lung injury, and points to strategies for intervention in the progression of inflammatory diseases. It had been shown that MST1R/CD136 plays a critical role in Ni-induced lung injury in mice. The overexpression of MSP, MT-SP1, and MST1R was a strong independent indicator of both metastasis and death in human breast cancer patients and significantly increased the accuracy of an existing gene expression signature for poor prognosis. Stimulation of MST1R leads to its transphosphorylation and the ultimate activation of numerous intracellular signaling pathways, such as the classical mitogen-activated protein kinase pathway, the phosphotidylinositol (PI)3-kinase pathway, and the JNK pathway.