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Anti-MLANA antibody

Cat.#: 141100

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Product Information

  • Product Name
    Anti-MLANA antibody
  • Documents
  • Description
    Rabbit Polyclonal to Human MLANA
  • Tested applications
    IHC-P
  • Species reactivity
    Human MLANA
  • Alternative names
    MART1 antibody; MART-1 antibody; Mart1 antibody; A930034P04Rik antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human MLANA, and purified by antigen affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    IHC-P: 1-10 μg/mL

  • Validations

    Human MLANA Immunohistochemistry(IHC) 14872

    Human MLANA Immunohistochemistry(IHC) 14872

    Human MLANA Immunohistochemistry(IHC) 14873

    Human MLANA Immunohistochemistry(IHC) 14873

  • Background
    MART-1 is a hydrophobic transmembrane protein without glycosylation sites highly enriched in early melanosomes. MART-1 is necessary for gp100 function, another antigen associated to cutaneous melanom, involved in the regulation of melanosome formation. MART-1 is expressed in skin and retinae melanocytes and in the majority of melanoma tumors, but it is absent from other tissues and tumors. It was isolated thanks to the specific recognition by T lymphocytes of MART-1 derived peptides, specially in the context of the HLA-A0201 haplotype, present in tumor infiltrates from melanoma patients. Thus, MART-1 is immunogenic in humans and has been widely exploited to induce anti-melanoma immunity in patients by means of several vaccination strategies.

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"