Anti-MCM7 Rabbit antibody
MCM7 Rabbit monoclonal antibody
WB, ICC/IF, FC
MCM2; CDC47; P85MCM; P1CDC47; PNAS146; PPP1R104; P1.1-MCM3 antibody
Antigen: A synthetic peptide of human MCM7
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
Western blot detection of MCM7 in K562,C6,3T3,Hela cell lysates using MCM7 Rabbit mAb(1:1000 diluted).Predicted band size:81kDa.Observed band size:81kDa.
Swiss-Prot Acc.P33993.Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.
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