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Product Name
Anti-MBD2 Rabbit antibody
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Description
MBD2 Rabbit monoclonal antibody
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Tested applications
WB, IHC-P, ICC/IF, FC, IP
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Species reactivity
Human, Mouse, Rat
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Alternative names
DMTase; NY-CO-41 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human MBD2
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Clonality
Monoclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
1:1000
1:20-1:500
1:100
1:20
1:20
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Validations
Western blot detection of MBD2 in Rat Brain,C6,3T3,Hela cell lysates using MBD2 Rabbit mAb(1:1000 diluted).Predicted band size:43kDa.Observed band size:43kDa.
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Background
Swiss-Prot Acc.Q9UBB5.Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"