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Product Name
Anti-LRP1 Rabbit antibody
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Description
LRP1 Rabbit polyclonal antibody
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Tested applications
WB, IHC-P, ICC/IF, IP, FC
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Species reactivity
Human, Mouse, Rat
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthesized peptide derived from human LRP1
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Clonality
Polyclonal
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Formulation
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/10000-1/20000
IHC: 1/50-1/100
ICC/IF: 1/50-1/100
IP: 1/30
FC: 1/50
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Validations
Western blot analysis of extracts from U87MG and Hela cells using LRP1 Rabbit pAb at 1:1000 dilution Predicted band size: 85kDa. Observed band size: 85kDa.
Immunohistochemical analysis of paraffin-embedded human liver carcinoma, using LRP1 Antibody.
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Background
Swiss-Prot Acc.Q07954.Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.Functions as a receptor for Pseudomonas aeruginosa exotoxin A.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"