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Product Name
Anti-KAT1/HAT1 Rabbit antibody
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Description
KAT1/HAT1 Rabbit polyclonal antibody
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Tested applications
WB, IHC-P, ICC/IF, FC, IP
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Species reactivity
Human, Mouse, Rat
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Alternative names
KAT1 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant protein of human KAT1
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
IHC: 1/100
ICC/IF: 1/100
FC: 1/20
IP: 1/20
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Validations
Western blot detection of KAT1 in K562,C6,3T3,Hela cell lysates using KAT1 Rabbit pAb(1:1000 diluted).Predicted band size:50kDa.Observed band size:45kDa.
Immunocytochemistry of KAT1(green) in Hela cells using KAT1 Rabbit pAb at dilution 1/50, and DAPI(blue)
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Background
Swiss-Prot Acc.O14929.Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"