Anti-IRAK4 antibody

Cat.#: 142867

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Product Information

  • Product Name
    Anti-IRAK4 antibody
  • Documents
  • Description
    Rabbit Polyclonal to Human IRAK4
  • Tested applications
    WB, ELISA
  • Species reactivity
    Human IRAK4
  • Alternative names
    9330209D03Rik antibody; IPD1 antibody; Irak4 antibody; IRAK4 antibody; IRAK-4 antibody; IRAK-4 antibody; NY-REN-64 antibody; NY-REN-64 antibody; REN64 antibody; IPD1 antibody; REN64 antibody; IRAK-4 antibody; NY-REN-64 antibody; IRAK-4 antibody; NY-REN-64 antibody; 8430405M07Rik antibody; 9330209D03Rik antibody; 8430405M07Rik antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Human IRAK4 . IRAK4 specific IgG was purified by Human IRAK4 affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    WB: 5-20 μg/ml

    ELISA: 0.1-0.2 μg/ml

    This antibody can be used at 0.1-0.2 μg/ml with the appropriate secondary reagents to detect Human IRAK4.

  • Validations

    IRAK4 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

    IRAK4 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

  • Background
    Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4 and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. It also phosphorylates IRAK1. A member of the IL-1 receptor (IL-1R)-associated kinase (IRAK) family, IRAK4, has been shown to play an essential role in Toll-like receptor (TLR)-mediated signaling. IL-1-mediated IRAK4 kinase activity in T cells is essential for induction of IL-23R expression, Th17 differentiation, and autoimmune disease. Pharmacological blocking of IRAK4 kinase activity will retain some levels of host defence, while reducing the levels and duration of inflammatory responses, which should provide beneficial therapies for sepsis and chronic inflammatory diseases. Defects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) which is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD. Defects in IRAK4 are also the cause of IRAK4 deficiency which causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"