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Product Name
Anti-Integrin linked ILK Rabbit antibody
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Description
Integrin linked ILK Rabbit monoclonal antibody
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Tested applications
WB, ICC/IF, FC, IP
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Species reactivity
Human, Mouse, Rat
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Alternative names
P59; ILK-1; ILK-2; p59ILK; HEL-S-28 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human Integrin linked ILK
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Clonality
Monoclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
1:1000-1:5000
1:20
1:20
1:20
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Validations
Western blot detection of Integrin linked ILK in C6,Hela cell lysates using Integrin linked ILK Rabbit mAb(1:1000 diluted).Predicted band size:51kDa.Observed band size:51kDa.
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Background
Swiss-Prot Acc.Q13418.Receptor-proximal protein kinase regulating integrin-mediated signal transduction (PubMed:8538749, PubMed:9736715). May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (PubMed:8538749, PubMed:9736715).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"