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Product Name
Anti-Integrin alpha 5 Rabbit antibody
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Description
Integrin alpha 5 Rabbit monoclonal antibody
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Tested applications
WB, IHC-P, ICC/IF, FC, IP
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Species reactivity
Human, Mouse, Rat
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Alternative names
FNRA; CD49e; VLA-5; VLA5A antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human Integrin alpha 5
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Clonality
Monoclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
1:1000-1:5000
1:50
1:100
1:20-1:100
1:20
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Validations
Western blot detection of Integrin alpha 5 in K562,3T3 cell lysates using Integrin alpha 5 Rabbit mAb(1:1000 diluted).Predicted band size:115kDa.Observed band size:150kDa.
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Background
Swiss-Prot Acc.P08648.Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"