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Product Name
Anti-IL16 antibody
- Documents
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Description
Rabbit monoclonal to IL16
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Tested applications
IHC-P
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Species reactivity
Human IL-16
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Alternative names
FLJ16806 antibody; FLJ42735 antibody; FLJ44234 antibody; IL16 antibody; Il16 antibody; IL-16 antibody; KIAA4048 antibody; LCF antibody; mKIAA4048 antibody; NIL16 antibody; PRIL16 antibody; prIL-16 antibody; IL-16 antibody; LCF antibody; NIL16 antibody; PRIL16 antibody; prIL-16 antibody; mKIAA4048 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human IL-16 (rh IL-16; AAC12732.1; Pro2-Ser130).
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Clonality
Monoclonal
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Formulation
0.2 μm filtered solution in PBS with 5% trehalose
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
IHC-P: 1-10 μg/mL
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Validations
IL-16 Antibody, Rabbit MAb, Immunohistochemistry
Immunochemical staining of human IL16 in human spleen with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
IL-16 Antibody, Rabbit MAb, Immunohistochemistry
Immunochemical staining of human IL16 in human tonsil with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
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Background
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
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References
- Maciaszek JW, et al. (1997) IL-16 represses HIV-1 promoter activity. J Immunol. 158(1): 5-8.
- Zhou P, et al. (1997) Human CD4+ cells transfected with IL-16 cDNA are resistant to HIV-1 infection: inhibition of mRNA expression. Nat Med. 3(6): 659-64.
- Theodore AC, et al. (1996) CD4 ligand IL-16 inhibits the mixed lymphocyte reaction. J Immunol. 157(5): 1958-64.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"