Anti-IL12RB1 antibody

Anti-IL12RB1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Human IL12RB1

WB, IP

Human IL12RB1 / CD212

IL-12R-BETA1 antibody; CD212 antibody; CD212 antibody; IL-12R[b] antibody; IL12RB antibody; Il12rb1 antibody; IL12RB1 antibody; MGC34454 antibody; CD212 antibody; IMD30 antibody; IL12RB antibody; IL-12R-BETA1 antibody; CD212 antibody; IL-12R[b] antibody

Rabbit IgG

Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human IL12RB1 / CD212, and purified by antigen affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Interleukin 12 receptor, beta 1 is also known as IL-12 receptor beta component, IL-12R subunit beta-1, and CD212 antigen (CD212). IL12RB1(CD212) is a subunit of the interleukin 12 receptor. IL12RB1(CD212) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. IL12RB1(CD212) forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of IL12RB1 and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. IL12RB1(CD212) Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. It associated with IL12RB2 it forms a functional, high affinity receptor for IL12. IL12RB1(CD212) associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.