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Human IL12RB1(CD212) (His Tag) recombinant protein

Cat.#: 501974

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Product Information

  • Product Name
    Human IL12RB1(CD212) (His Tag) recombinant protein
  • Documents
  • Description
    Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
  • Protein name
    Interleukin-12 receptor subunit beta-1
  • Protein short names
    IL-12R[B]; MGC34454; IMD30; CD212; IL12RB; IL-12R-BETA1; IL12RB1
  • Uniprot ID
    P42701
  • Gene Name
    IL12RB1; IL12R; IL12RB
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human IL12RB1 isoform 1 (NP_005526.1) extracellular domain (Met 1-Glu 540) was expressed, fused with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human IL12RB1 consists of 528 amino acids and predictes a molecular mass of 58.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhIL12RB1 is approximately 70 kDa due to glycosylation.
  • Purity
    > 94 % as determined by SDS-PAGE
  • Activity
    Measured by its binding ability in a functional ELISA. Immobilized human IL12RB1 at 20 μg/ml (100 μl/well) can bind human IL12B with a linear ranger of 2.56-64 ng/ml.
  • Validations

    Human IL12RB1 / IL12RB / CD212 Protein (His Tag) SDS-PAGE

    Human IL12RB1 / IL12RB / CD212 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"