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Product Name
Anti-IGF1 Receptor Rabbit antibody
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Description
IGF1 Receptor Rabbit monoclonal antibody
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Tested applications
WB, ICC/IF, FC, IP
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Species reactivity
Human
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant protein of human IGF1 Receptor
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Clonality
Monoclonal
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Formulation
50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA
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Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/1000
ICC/IF: 1/20
FC: 1/50
IP: 1/20
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Validations
Western blot detection of IGF1 Receptor in Hela,A549,MCF-7,U251 cell lysates using IGF1 Receptor Rabbit mAb(1:1000 diluted).Predicted band size:155kDa.Observed band size:95kDa.
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Background
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"