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  • Anti-hnRNP K Rabbit antibody

Anti-hnRNP K Rabbit antibody

Cat.#: 168939

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Product Information

  • Product Name
    Anti-hnRNP K Rabbit antibody
  • Documents
  • Description
    hnRNP K Rabbit monoclonal antibody
  • Tested applications
    WB, IHC-P
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    AUKS; CSBP; TUNP; HNRPK antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human hnRNP K
  • Clonality
    Monoclonal antibody
  • Formulation
    50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/1000-1/5000

    IHC: 1/20-1/50

  • Validations

    Western blot detection of hnRNP K in K562,PC3,Hela cell lysates using hnRNP K Rabbit mAb(1:500 diluted).Predicted band size:51kDa.Observed band size:62kDa.

    Western blot detection of hnRNP K in K562,PC3,Hela cell lysates using hnRNP K Rabbit mAb(1:500 diluted).Predicted band size:51kDa.Observed band size:62kDa.

  • Background
    Swiss-Prot Acc.P61978.One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction . As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"