Anti-Granzyme B/GZMB antibody

Anti-Granzyme B/GZMB antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Mouse monoclonal to Granzyme B/GZMB

ELISA, IHC-P

Human Granzyme B / GZMB

CCP1 antibody; HLP antibody; CCPI antibody; CGL1 antibody; CSPB antibody; SECT antibody; CGL-1 antibody; CSP-B antibody; CTLA1 antibody; CTSGL1 antibody; GZB antibody; Ctla1 antibody; Ctla-1 antibody; AI553453 antibody; CCP-1/C11 antibody; AI553453 antibody; CCP1 antibody; CCP-1/C11 antibody; CCPI antibody; CGL1 antibody; CGL-1 antibody; CSPB antibody; CSP-B antibody; Ctla1 antibody; CTLA1 antibody; Ctla-1 antibody; CTSGL1 antibody; Gamb antibody; Granzyme B antibody; Granzyme B antibody; GZB antibody; GZMB antibody; HLP antibody; SECT antibody

Mouse IgG2b

This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Granzyme B (rhGranzyme B; NP_004122.1; Met 1-Tyr 247). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.

Monoclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 30 substrates of GZMB have been identified including the key substrate caspase-3, ICAD and Bid. GZMB is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells, and accordingly plays an essential role in immunosurveillance.