-
Product Name
Anti-GNA13 Rabbit antibody
- Documents
-
Description
GNA13 Rabbit monoclonal antibody
-
Tested applications
WB, IHC-P
-
Species reactivity
Human, Mouse, Rat
-
Alternative names
G13 antibody
-
Isotype
Rabbit IgG
-
Preparation
Antigen: A synthetic peptide of human G protein alpha 13
-
Clonality
Monoclonal
-
Formulation
50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
-
Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
-
Applications
WB: 1/1000-1/5000
IHC: 1/200
-
Validations
Western blot detection of GNA13 [KO Validated] in Hela,Jurkat cell lysates using GNA13 Rabbit mAb [KO Validated](1:500 diluted).Predicted band size:44kDa.Observed band size:44kDa.
-
Background
Swiss-Prot Acc.Q14344.Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) . Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333).
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"