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Product Name
Anti-FOXO4 Rabbit antibody
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Description
FOXO4 Rabbit monoclonal antibody
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Tested applications
WB, ICC/IF, FC, IP
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Species reactivity
Human, Mouse, Rat
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Alternative names
AFX; AFX1; MLLT7 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human FOXO4
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Clonality
Monoclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
1:1000-1:5000
1:20-1:50
1:20-1:100
1:20-1:50
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Validations
Western blot detection of FOXO4 in K562,C6,3T3 cell lysates using FOXO4 Rabbit mAb(1:1000 diluted).Predicted band size:54kDa.Observed band size:65kDa.
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Background
Swiss-Prot Acc.P98177.Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"