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Product Name
Anti-Fibrillarin Rabbit antibody
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Description
Fibrillarin Rabbit polyclonal antibody
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Tested applications
WB, FC, IP
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Species reactivity
Human, Mouse, Rat
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Alternative names
FIB; FLRN; Nop1; RNU3IP1 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human Fibrillarin
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
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Validations
Western blot detection of Fibrillarin in K562,C6,3T3 cell lysates using Fibrillarin Rabbit pAb(1:1000 diluted).Predicted band size:34kDa.Observed band size:34kDa.
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Background
Swiss-Prot Acc.P22087.S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"