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Product Name
Anti-FBP1 Rabbit antibody
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Description
FBP1 Rabbit polyclonal antibody
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Tested applications
WB, IHC-P
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Species reactivity
Human, Mouse, Rat
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Alternative names
FBP antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human FBP1
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000-1/5000
IHC: 1/20-1/50
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Validations
Immunohistochemistry of FBP1 in paraffin-embedded Human lung cancer tissue using FBP1 Rabbit pAb at dilution 1/20
Western blot detection of FBP1 in Rat Brain lysates using FBP1 Rabbit pAb(1:1000 diluted).Predicted band size:37kDa.Observed band size:37kDa.
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Background
Swiss-Prot Acc.P09467.Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"