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  • Anti-EHD1 Rabbit antibody

Anti-EHD1 Rabbit antibody

Cat.#: 168902

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Special Price 441.3 USD

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Product Information

  • Product Name
    Anti-EHD1 Rabbit antibody
  • Documents
  • Description
    EHD1 Rabbit monoclonal antibody
  • Tested applications
    WB, ICC/IF, FC, IP
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    PAST; PAST1; H-PAST; HPAST1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human EHD1
  • Clonality
    Monoclonal antibody
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    1:2000-1:10000

    1:20-1:50

    1:100-1:500

    1:20-1:50

  • Validations

    Western blot detection of EHD1 in K562,Rat Brain,C6,3T3 cell lysates using EHD1 Rabbit mAb(1:1000 diluted).Predicted band size:61kDa.Observed band size:61kDa.

    Western blot detection of EHD1 in K562,Rat Brain,C6,3T3 cell lysates using EHD1 Rabbit mAb(1:1000 diluted).Predicted band size:61kDa.Observed band size:61kDa.

  • Background
    Swiss-Prot Acc.Q9H4M9.ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (PubMed:24019528). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:20801876). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth . Plays a role in myoblast fusion . Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing . Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed:25686250).
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"