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Product Name
Anti-DNAJB6 Rabbit antibody
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Description
DNAJB6 Rabbit polyclonal antibody
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Tested applications
WB, IHC-P, FC
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Species reactivity
Human, Mouse, Rat
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Alternative names
DJ4; MRJ; DnaJ; HSJ2; HHDJ1; HSJ-2; MSJ-1; LGMD1D; LGMD1E antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant protein of human DNAJB6
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
IHC: 1/20
FC: 1/50
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Validations
Immunohistochemistry of DNAJB6 in paraffin-embedded Human lung cancer tissue using DNAJB6 Rabbit pAb at dilution 1/20
Western blot detection of DNAJB6 in K562,Rat Brain,C6,3T3,Hela cell lysates using DNAJB6 Rabbit pAb(1:1000 diluted).Predicted band size:36kDa.Observed band size:36kDa.
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Background
Swiss-Prot Acc.O75190.Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.
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