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  • Anti-CXCL16 / SR-PSOX antibody

Anti-CXCL16 / SR-PSOX antibody

Cat.#: 101289

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Product Information

  • Product Name
    Anti-CXCL16 / SR-PSOX antibody
  • Documents
  • Description
    Rabbit polyclonal to CXCL16 / SR-PSOX
  • Tested applications
    ELISA, WB
  • Species reactivity
    Mouse CXCL16 / SR-PSOX
  • Alternative names
    0910001K24Rik antibody; AV290116 antibody; BB024863 antibody; CXCL16 antibody; CXCL16 antibody; CXCLG16 antibody; DN-491F10.6 antibody; SRPSOX antibody; SR-PSOX antibody; SR-PSOX antibody; Zmynd15 antibody; SRPSOX antibody; CXCLG16 antibody; SR-PSOX antibody; SR-PSOX antibody; Zmynd15 antibody; AV290116 antibody; BB024863 antibody; CXCL16v1 antibody; CXCL16v2 antibody; b2b498Clo antibody; 0910001K24Rik antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Mouse CXCL16 / SR-PSOX (rh CXCL16 / SR-PSOX; NP_075647.3; Met1-Trp201). CXCL16 / SR-PSOX specific IgG was purified by Mouse CXCL16 / SR-PSOX affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    WB: 5-10 μg/mL

    ELISA: 0.1-0.2 μg/mL

    This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse CXCL16 / SR-PSOX. The detection limit for Mouse CXCL16 / SR-PSOX is < 0.039 ng/well.

  • Validations

    CXCL16 / SR-PSOX Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

    CXCL16 / SR-PSOX Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

  • Background
    C-X-C motif chemokine 16, also known as Small-inducible cytokine B16, SR-PSOX, and CXCL16, is a single-pass type I membrane protein which belongs to the intercrine alpha (chemokine CxC) family. CXCL16 exists in transmembrane and soluble forms. The transmembrane form acts as a scavenger receptor for oxidised LDL whereas the soluble form acts a chemoattractant for mainly CD8+ T cells. CXCL16 is a protein which shares pattern recognition receptor functions, relevant for adhesion and phagocytosis of bacterial products, with the properties of an adhesion molecule and inflammatory chemokine. CXCL16/SR-PSOX is an interferon-gamma-regulated chemokine and scavenger receptor for oxidized low-density lipoprotein that is expressed in atherosclerotic lesions. Proteolytic cleavage of membrane-bound CXCL16 releases soluble CXCL16, which may promote migration of effector T cells and augment a proatherogenic inflammatory response. CXCL16/SR-PSOX can be a potential player in atherogenesis. Enhanced expression of CXCL16 has been demonstrated in atherosclerotic plaques and several properties have been attributed to CXCL16 that could influence the atherosclerotic process. Following in vitro studies suggested that as an adhesion molecule CXCL16/SR-PSOX might mediate T-cell adhesion to the endothelium, as a chemokine-drive T-cell migration, stimulate cell proliferation and elicit inflammatory phenotype in smooth muscle cells (SMC) and, finally, as a scavenger receptor-mediate uptake of atherogenic lipoproteins by macrophages and SMC. CXCR6 and its ligand CXCL16 in regulating metastasis and invasion of cancer. CXCR6 and CXCL16 are up-regulated in multiple cancer tissue types and cancer cell lines relative to normal tissues and cell lines. In addition, both CXCR6 and CXCL16 levels increase as tumor malignancy increases. Thus, CXCL16 and CXCR6 may mark cancers arising in an inflammatory milieu and mediate pro-tumorigenic effects of inflammation through direct effects on cancer cell growth and by inducing the migration and proliferation of tumor-associated leukocytes.
  • References
    • Sheikine Y, et al. (2008) CXCL16/SR-PSOX--a friend or a foe in atherosclerosis? Atherosclerosis. 197(2): 487-95.
    • Lehrke M, et al. (2008) CXCL16 is a surrogate marker of inflammatory bowel disease. Scand J Gastroenterol. 43(3): 283-8.
    • Jansson AM, et al. (2009) Soluble CXCL16 predicts long-term mortality in acute coronary syndromes. Circulation. 119(25): 3181-8.
    • Darash-Yahana M, et al. (2009) The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers. PLoS One. 4(8): e6695.
    • Deng L, et al. (2010) CXCR6/CXCL16 functions as a regulator in metastasis and progression of cancer. Biochim Biophys Acta. 1806(1): 42-9.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"