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Product Name
Anti-COX2/cyclooxygenase2 Rabbit antibody
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Description
COX2/cyclooxygenase2 Rabbit monoclonal antibody
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Tested applications
WB, IHC-P
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Species reactivity
Human, Mouse
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Alternative names
COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human COX2
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Clonality
Monoclonal
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Formulation
50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/1000
IHC: 1/20
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Validations
Western blot detection of COX-2/cyclooxygenase-2 in Rat Brain lysates using COX-2/cyclooxygenase-2 Rabbit mAb(1:500 diluted).Predicted band size:69kDa.Observed band size:69kDa.
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Background
Swiss-Prot Acc.P35354.Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis (PubMed:26859324, PubMed:27226593). Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"