Anti-COX2/Cyclooxygenase 2 Rabbit antibody

Cat.#: 166950

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Product Information

  • Product Name
    Anti-COX2/Cyclooxygenase 2 Rabbit antibody
  • Documents
  • Description
    COX2/Cyclooxygenase 2 Rabbit polyclonal antibody
  • Tested applications
    WB, ICC/IF, FC, IP
  • Species reactivity
    Human, Mouse
  • Alternative names
    COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant protein of human COX2/Cyclooxygenase 2
  • Clonality
    Polyclonal
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at -20°C. Stable for 12 months from date of receipt.
  • Applications

    WB: 1/1000

    ICC/IF: 1/50

    FC: 1/100

    IP: 1/20

  • Validations

    Western blot detection of COX2/Cyclooxygenase 2 in 3T3 cell lysates using COX2/Cyclooxygenase 2 Rabbit pAb(1:1000 diluted).Predicted band size:69KDa.Observed band size:74KDa.

    Western blot detection of COX2/Cyclooxygenase 2 in 3T3 cell lysates using COX2/Cyclooxygenase 2 Rabbit pAb(1:1000 diluted).Predicted band size:69KDa.Observed band size:74KDa.

  • Background
    Swiss-Prot Acc.P35354.Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis (PubMed:26859324, PubMed:27226593). Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"