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Product Name
Anti-Coagulation Factor IX / FIX / F9 antibody
- Documents
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Description
Rabbit polyclonal to Coagulation Factor IX / FIX / F9
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Tested applications
ELISA, WB
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Species reactivity
Human Coagulation Factor IX / F9
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Alternative names
FIX antibody; PTC antibody; HEMB antibody; THPH8 antibody; Cf9 antibody; Cf-9 antibody; AW111646 antibody; Cf9 antibody; Cf-9 antibody; Coagulation Factor IX antibody; Coagulation Factor IX antibody; F9 antibody; F9 antibody; FIX antibody; FIX antibody; HEMB antibody; MGC129642 antibody; P19 antibody; PTC antibody; RP23-419J18.1 antibody; RP6-88D7.1 antibody; AW111646 antibody; MGC129641 antibody; p19 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Human Coagulation Factor IX / F9 (rh Coagulation Factor IX / F9; AAB59620.1; Met 1-Thr 461). Coagulation Factor IX / F9 specific IgG was purified by Human Coagulation Factor IX / F9 affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS with 5% trehalose
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 2-10 μg/mL
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human F9. The detection limit for Human F9 is approximately 0.00975 ng/well.
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Validations
Coagulation Factor IX / FIX / F9 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
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Background
Coagulation factor IX, also known as Christmas factor, Plasma thromboplastin component and PTC, is a secreted protein which belongs to the peptidase S1 family. Coagulation factor IX / F9 contains two EGF-like domains, one Gla (gamma-carboxy-glutamate) domain and one?peptidase S1 domain. Coagulation factor IX / F9 is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca2+ons, phospholipids, and factor VIIIa. Defects in Coagulation factor IX / F9 are the cause of thrombophilia due to factor IX defect which is a hemostatic disorder characterized by a tendency to thrombosis. Defects in Coagulation factor IX / F9 are also the cause of recessive X-linked hemophilia B ( HEMB ) which also known as Christmas disease.
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References
- Onay U.V., et al., 2003, Br. J. Haematol. 120:656-659.
- Vidal F., et al., 2000, Br. J. Haematol. 111:549-551.
- Simioni P., et al., 2009, N. Engl. J. Med. 361:1671-1675.
- Espinos C., et al., 2009, Haematologica 88:235-236.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"