Anti-CLIC4 antibody

Anti-CLIC4 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to CLIC4

ELISA, WB, IP

Human CLIC4

H1 antibody; huH1 antibody; p64H1 antibody; CLIC4L antibody; MTCLIC antibody; TU-74 antibody; mc3s5 antibody; D0Jmb3 antibody; mtCLIC antibody; Clic4 antibody; CLIC4L antibody; D0Jmb3 antibody; H1 antibody; huH1 antibody; RP23-230K10.1 antibody; CLIC4 antibody; DKFZp566G223 antibody; FLJ38640 antibody; mc3s5 antibody; mtCLIC antibody; MTCLIC antibody; p64H1 antibody; TU-74 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human CLIC4 (rh CLIC4; Q9Y696-1; Ala 2-Lys 253). CLIC4 specific IgG was purified by Human CLIC4 affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Chloride intracellular channel protein 4, also known as Intracellular chloride ion channel protein p64H1 and CLIC4, is a member of the chloride channel CLIC family. It contains one GST C-terminal domain. CLIC4 is a member of a family of intracellular chloride channels. It is regulated by p53, c-Myc, and tumor necrosis factor-alpha. CLIC4 is detected in epithelial cells from colon, esophagus and kidney (at protein level). CLIC4 has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. CLIC4 could promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Expression of CLIC4 is prominent in heart, kidney, placenta and skeletal muscle. Overexpression of CLIC4 in cancer cells inhibits tumor growth. Conversely, overexpression of CLIC4 in tumor stromal cells stimulates tumor growth. Thus, CLIC4 participates in normal and pathological processes and may serve as a useful target for therapies in disturbances of homeostasis and neoplastic transformation. Loss of CLIC4 in tumor cells and gain in tumor stroma is common to many human cancers and marks malignant progression. Up-regulation of CLIC4 in tumor stroma is coincident with myofibroblast conversion, generally a poor prognostic indicator. Reactivation and restoration of CLIC4 in tumor cells or the converse in tumor stromal cells could provide a novel approach to inhibit tumor growth.

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