Anti-CD6 / Cluster of Differentiation 6 antibody

Cat.#: 101679

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Product Information

  • Product Name
    Anti-CD6 / Cluster of Differentiation 6 antibody
  • Documents
  • Description
    Rabbit monoclonal to CD6 / Cluster of Differentiation 6
  • Tested applications
    FCM
  • Species reactivity
    Mouse CD6 / Cluster of Differentiation 6
  • Alternative names
    Cd6 antibody; FLJ44171 antibody; TP120 antibody; CD6 antibody; TP120 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD6 / Cluster of Differentiation 6 (rM CD6 / Cluster of Differentiation 6; Q91WN5; Met1-Gly396).
  • Clonality
    Monoclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    IHC-P: 1-10 μg/mL

    FCM: 0.5-2 μg/Test

  • Validations

    CD6 / Cluster of Differentiation 6 Antibody, Rabbit MAb, Flow Cytometry

    CD6 / Cluster of Differentiation 6 Antibody, Rabbit MAb, Flow Cytometry

    Flow cytometric analysis of CD6 expression on BABL/c splenocytes. Cells were stained with purified anti-Mouse CD6, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

  • Background
    T-cell differentiation antigen CD6, also known as TP120 and CD6, is a single-pass type I membrane protein which contains three SRCR domains. CD6 / TP120 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP120 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP120 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP120 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse.
  • References
    • Joo YS. et al., 2000, Arthritis Rheum. 43 (2): 329-35.
    • Singer NG. et al., 2002, Int Immunol. 14 (6): 585-97.
    • Gimferrer I. et al., 2005, J Immunol. 175 (3): 1406-14.
    • Alonso R. et al., 2010, J Autoimmun. 35 (4): 336-41.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"