Anti-CD6 / Cluster of Differentiation 6 antibody

Anti-CD6 / Cluster of Differentiation 6 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit monoclonal to CD6 / Cluster of Differentiation 6

IF, ICC/IF

Mouse CD6 / Cluster of Differentiation 6

Cd6 antibody; FLJ44171 antibody; TP120 antibody; CD6 antibody; TP120 antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD6 / Cluster of Differentiation 6 (rM CD6 / Cluster of Differentiation 6; Q91WN5; Met1-Gly396).

Monoclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

T-cell differentiation antigen CD6, also known as TP120 and CD6, is a single-pass type I membrane protein which contains three SRCR domains. CD6 / TP120 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP120 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP120 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP120 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse.

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