Anti-CD28 antibody

Cat.#: 142474

Special Price 109.7 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Anti-CD28 antibody
  • Documents
  • Description
    Monoclonal antibody to Human CD28
  • Tested applications
    FCM, Func/A
  • Species reactivity
    Human CD28
  • Alternative names
    Cd28 antibody; CD28 antibody; CH29-189K17.3 antibody; MGC138290 antibody; Tp44 antibody; Tp44 antibody
  • Isotype
    Human IgG2
  • Formulation
    0.2 μm filtered solution in Histidine and Arginine buffer containing 120mM NaCl, 0.02% Tween 80, pH6.0
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    Agonist Activity – Human CD28 antibody induce IL2 secretion of the CD4+ T cells. The activating titer (EC50) is typically 0.15­0.6 μg/mL in the presence of 2 μg/mL Human CD3 (humanized OKT3) antibody(catalog number:#141802) coated on the cell culture plate.

    FCM: 0.5-2 μg/Test

  • Validations

    Human CD28 Antibody, Agonist Activity

    Human CD28 Antibody, Agonist Activity

    Human CD28 Antibody

    Human CD28 Antibody

    Human CD28 Antibody

    Human CD28 Antibody

  • Background
    CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. Mouse CD28 is constitutively expressed on the surface of all murine T cells and on developing thymocytes as disulfide-linked homodimers or as monomers. CD28 can binds the B7-1 and B7-2 ligand, and together perform important functions in the T and B cell response pathways. B7/CD28 family members, which can augment or antagonize T-cell receptor signaling, in the regulation of central and peripheral T-cell tolerance. CD28 is thus involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.

    Immune Checkpoint
    Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IHC Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
    Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

    Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"