Anti-CD166 Rabbit antibody

Cat.#: 167286

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Product Information

  • Product Name
    Anti-CD166 Rabbit antibody
  • Documents
  • Description
    CD166 Rabbit polyclonal antibody
  • Tested applications
    WB, IHC-P, ICC/IF, FC, IP
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    MEMD; CD166 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human CD166
  • Clonality
    Polyclonal
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at -20°C. Stable for 12 months from date of receipt.
  • Applications

    WB: 1/2000

    IHC: 1/50

    ICC/IF: 1/50

    FC: 1/20

    IP: 1/20

  • Validations

    Western blot detection of CD166 in Rat Brain,C6 cell lysates using CD166 Rabbit pAb(1:1000 diluted).Predicted band size:65kDa.Observed band size:105kDa.

    Western blot detection of CD166 in Rat Brain,C6 cell lysates using CD166 Rabbit pAb(1:1000 diluted).Predicted band size:65kDa.Observed band size:105kDa.

    Immunohistochemistry of CD166 in paraffin-embedded Human breast cancer tissue using CD166 Rabbit pAb at dilution 1/50

    Immunohistochemistry of CD166 in paraffin-embedded Human breast cancer tissue using CD166 Rabbit pAb at dilution 1/50

  • Background
    Swiss-Prot Acc.Q13740.Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:7760007, PubMed:15496415, PubMed:15048703, PubMed:16352806, PubMed:23169771, PubMed:24945728). Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806). Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation . Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons .

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"