Anti-CASQ1 antibody

Anti-CASQ1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Human CASQ1

WB, ELISA, IHC-P, IP

Human Calsequestrin-1 / CASQ1

calsequestrin 1 (fast-twitch antibody; skeletal muscle) antibody; CASQ1 antibody; RP11-536C5.6 antibody; CASQ antibody; PDIB1 antibody; calmitin antibody; calmitine antibody; calsequestrin antibody; skeletal muscle isoform antibody; calsequestrin-1 antibody; calsequestrin 1 antibody; Casq1 antibody; CSQ antibody; CSQ-1 antibody; CSQ1 antibody; sCSQ antibody; calsequestrin antibody; skeletal muscle isoform antibody; CASQ antibody; PDIB1 antibody; VMCQA antibody; CSQ antibody; CSQ1 antibody; sCSQ antibody; CSQ-1 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human Calsequestrin-1 / CASQ1 . Calsequestrin-1 / CASQ1 specific IgG was purified by Human Calsequestrin-1 / CASQ1 affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Calsequestrin-1 is an isoform of calsequestrin. Calsequestrin is a calcium-binding protein of the sarcoplasmic reticulum. It helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction, even though the concentration of calcium in the sarcoplasmic reticulum is much higher than in the cytosol. Two forms of calsequestrin have been identified: Calsequestrin-2 and Calsequestrin-1. Calsequestrin-1 is found in fast skeletal muscle. The release of calsequestrin-bound calcium (through a calcium release channel) triggers muscle contraction. The active protein is not highly structured, more than 50% of it adopting a random coil conformation. When calcium binds there is a structural change whereby the alpha-helical content of the protein increases from 3 to 11%. Both forms of calsequestrin are phosphorylated by casein kinase 2, but the cardiac form is phosphorylated more rapidly and to a higher degree. Calsequestrin-1 is also secreted in the gut where it deprives bacteria of calcium ions.