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Product Name
Anti-CaMKII alpha Rabbit antibody
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Description
CaMKII alpha Rabbit polyclonal antibody
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Tested applications
WB, ICC/IF, FC
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Species reactivity
Human, Mouse, Rat
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Alternative names
CAMKA; MRD53; MRT63; CaMKIINalpha antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human CaMKII
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000-1/2000
ICC/IF: 1/20-1/100
FC: 1/20-1/100
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Validations
Western blot detection of CaMKII alpha in Rat Brain,Hela cell lysates using CaMKII alpha Rabbit pAb(1:1000 diluted).Predicted band size:54kDa.Observed band size:54kDa.
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Background
Swiss-Prot Acc.Q9UQM7.Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission . Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"