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Product Name
Anti-CALD1 Rabbit antibody
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Description
CALD1 Rabbit polyclonal antibody
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Tested applications
WB, IHC-P, ICC/IF, FC, IP
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Species reactivity
Human, Mouse, Rat
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Alternative names
CDM; HCAD; LCAD; H-CAD; L-CAD; NAG22 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human Caldesmon
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/2000-1/10000
IHC: 1/20
ICC/IF: 1/50-1/200
FC: 1/20
IP: 1/20
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Validations
Immunohistochemistry of Caldesmon in paraffin-embedded Human colon cancer tissue using Caldesmon Rabbit pAb at dilution 1/20
Western blot detection of CALD1 in C6,3T3,Hela cell lysates using CALD1 Rabbit pAb(1:1000 diluted).Predicted band size:93kDa.Observed band size:70-80kDa.
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Background
Swiss-Prot Acc.Q05682.Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration .
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"