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Product Name
Anti-Bax Rabbit antibody
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Description
Bax Rabbit polyclonal antibody
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Tested applications
WB, IP
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Species reactivity
Human, Mouse, Rat
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Alternative names
BCL2L4 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human Bax
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
IP: 1/20
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Validations
Western blot detection of Bax in C6,3T3,Hela cell lysates using Bax Rabbit pAb(1:1000 diluted).Predicted band size:21kDa.Observed band size:21kDa.
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Background
Swiss-Prot Acc.Q07812.Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"