Anti-APOH antibody

Anti-APOH antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Rat APOH

WB, ELISA

Rat Apolipoprotein H / APOH

BG antibody; B2G1 antibody; B2GP1 antibody; B2GPI antibody; beta2-GPI antibody; beta-2-GPI antibody; APOH antibody; Apoh antibody; Apolipoprotein H antibody; Apolipoprotein H antibody; B2G1 antibody; B2GPI antibody; beta2-GPI antibody; beta-2-GPI antibody; BG antibody; RP23-261J24.1 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Rat Apolipoprotein H / APOH . Apolipoprotein H / APOH specific IgG was purified by Rat Apolipoprotein H / APOH affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Apolipoprotein H (APOH), also known as Beta-2-glycoprotein 1, Activated protein C-binding protein, B2GPI, and B2G1, is a glycoprotein synthesized by liver cells and it is present in the blood associated with plasma lipoproteins. It is an essential cofactor for the binding of certain antiphospholipid antibodies (APA) to anionic phospholipid. APOH binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. APOH may prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. APOH appears to completely inhibit serotonin release by the platelets and prevents subsequent waves of the ADP-induced aggregation. The activity of APOH appears to involve the binding of agglutenating, negatively charged compounds, and inhibits agglutenation by the contact activation of the intrinsic blood coagulation pathway. APOH causes a reduction of the prothrombinase binding sites on platelets and reduces the activation caused by collagen when thrombin is present at physiological serum concentrations of APOH suggesting a regulatory role of APOH in coagulation. APOH plasma concentrations are strongly associated to metabolic syndrome alterations and vascular disease in type 2 diabetic and could be considered as a clinical marker of cardiovascular risk. APOH is found on several classes of lipoproteins, and is involved in the activation of lipoprotein lipase in lipid metabolism. This single-chain glycoprotein also has been implicated in several physiologic pathways including coagulation and the production of hypertension, which are related to the pathogenesis of primary cerebral hemorrhage (PICH).