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Product Name
Anti-AMPK beta 1 Mouse antibody
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Description
AMPK beta 1 Mouse monoclonal antibody
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Tested applications
WB
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Species reactivity
Human
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Isotype
Mouse IgG
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Preparation
Antigen: Recombinant Protein of AMPKβ1.
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Clonality
Monoclonal
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Formulation
Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide 50% glycerol 0.1%BSA
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Storage instructions
Store at -20°C
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Applications
1:1000
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Validations
Western blot detection of AMPKβ1 in Hela,COS7 cell lysates using AMPK beta 1 Mouse mAb(1:1000 diluted).Predicted band size:38KDa.Observed band size:38KDa.
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Background
Swiss-Prot Acc.Q9Y478.Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"