Cart 2

Amyloid beta (A4) precursor protein antibody

Cat.#: 107124

Size:

Special Price 239.0 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Amyloid beta (A4) precursor protein antibody
  • Documents
  • Description
    Amyloid beta (A4) precursor protein Mouse Monoclonal antibody. Positive IHC detected in human gliomas tissue. Positive WB detected in Y79 cells, HEK-293 cells. Observed molecular weight by Western-blot: 100 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human, Pig; other species not tested.
  • Alternative names
    AAA antibody; ABETA antibody; ABPP antibody; AD1 antibody; AICD 50 antibody; AICD 57 antibody; AICD 59 antibody; AID(50) antibody; AID(57) antibody; AID(59) antibody; Amyloid beta A4 protein antibody; amyloid P antibody; APP antibody; APPI antibody; beta Amyloid antibody; CTFgamma antibody; CVAP antibody; Gamma CTF(50) C31 antibody; PN II antibody; PN2 antibody; PreA4 antibody; Protease nexin II antibody; S APP alpha Soluble APP beta antibody
  • Isotype
    Mouse IgG2a
  • Preparation
    This antibody was obtained by immunization of Amyloid beta (A4) precursor protein recombinant protein (Accession Number: BC004369). Purification method: Protein A purified.
  • Clonality
    Monoclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    Y79 cells were subjected to SDS PAGE followed by western blot with Catalog No:107584(APP Antibody) at dilution of 1:1000

    Y79 cells were subjected to SDS PAGE followed by western blot with Catalog No:107584(APP Antibody) at dilution of 1:1000

    Immunohistochemistry of paraffin-embedded human gliomas tissue slide using Catalog No:107584(APP Antibody) at dilution of 1:200 (under 10x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

    Immunohistochemistry of paraffin-embedded human gliomas tissue slide using Catalog No:107584(APP Antibody) at dilution of 1:200 (under 10x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

    Immunohistochemistry of paraffin-embedded human gliomas tissue slide using Catalog No:107584(APP Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

    Immunohistochemistry of paraffin-embedded human gliomas tissue slide using Catalog No:107584(APP Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

  • Background
    Aβ derives from APP via proteolytic cleavage by proteases called α-, β- and γ-secretase. The α-secretase cleavage precludes the formation of Aβ, while the β- and γ-cleavages generate APP components with amyloidogenic features. Amyloid beta A4 precursor protein(APP), encoded by APP gene which locate on human chromosome 21q, is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain, kidney, heart and spleen, but weak in liver. Defects in APP are the cause of Alzheimer disease type 1 (AD1).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"