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  • Aldolase C antibody
  • Aldolase C antibody

Aldolase C antibody

Cat.#: 107978

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Product Information

  • Product Name
    Aldolase C antibody
  • Documents
  • Description
    Aldolase C Rabbit Polyclonal antibody. Positive WB detected in mouse cerebellum tissue, human heart tissue, K-562 cells, mouse brain tissue. Positive IF detected in HepG2 cells. Observed molecular weight by Western-blot: 40kd
  • Tested applications
    ELISA, WB, IF
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    ALDOC antibody; Aldolase C antibody; Brain type aldolase antibody; Fructose bisphosphate aldolase C antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Aldolase C recombinant protein (Accession Number: BC003613). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IF: 1:10-1:100

  • Validations

    mouse cerebellum tissue were subjected to SDS PAGE followed by western blot with Catalog No:107978(ALDoc antibody) at dilution of 1:800

    mouse cerebellum tissue were subjected to SDS PAGE followed by western blot with Catalog No:107978(ALDoc antibody) at dilution of 1:800

    Immunofluorescent analysis of HepG2 cells, using ALDoc antibody Catalog No:107978 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

    Immunofluorescent analysis of HepG2 cells, using ALDoc antibody Catalog No:107978 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

  • Background
    Fructose-bisphosphate aldolase C (ALDoc) reversibly cleaves FBP and F1-P to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate and is strongly expressed in mammalian brain together with ALDOA and is alsopresent in the heart and spleen of some species(PMID:9363598). It is involed in glycolysis as an important enzyme. Phospholipase D2 and inositol 1,4,5-triphosphate interact with ALDoc in signal transduction. Meanwhile, the protein expression of ALDoc has been reported to be regulated in brain tumor, hepatomas, and lung cancer(PMID:21548097).
  • References
    • Zhao W, Jiang B, Hu H. Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain. Human molecular genetics. 24(16):4686-97. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"