ALADIN antibody

ALADIN antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

ALADIN Rabbit Polyclonal antibody. Positive IHC detected in human stomach cancer tissue. Positive IF detected in COS-7 cells, Hela cells. Positive WB detected in SH-SY5Y cells, HeLa cells. Observed molecular weight by Western-blot: 60 kDa

ELISA, WB, IHC, IF

Human; other species not tested.

AAA antibody; AAAS antibody; AAASb antibody; ADRACALA antibody; ADRACALIN antibody; ALADIN antibody; DKFZp586G1624 antibody; GL003 antibody

Rabbit IgG

This antibody was obtained by immunization of ALADIN recombinant protein (Accession Number: NM_015665). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

The AAAS gene product is the 60 kDa nuclear pore complex (NPC) protein alacrima-achalasia-adrenal insufficiency neurological disorder (ALADIN). AAAS mRNA and the ALADIN protein are ubiquitously expressed with predominance in the adrenal and central nervous system structures in human and rat. ALADIN, a Tryptophan-Aspartic acid (WD) repeat containing protein, was the first nuclear pore complex protein to be associated with hereditary neurodegenerative disease and the only nuclear pore complex protein to be associated with hereditary adrenal disease. ALADIN's precise function at the nuclear pore complex is unknown. Most naturally occurring AAAS mutations result in mislocalization of the abnormal ALADIN protein (mainly into the cytoplasm), implying that correct NPC targeting is vital for its function. (PMID: 23825130)

• Carvalhal S, Ribeiro SA, Arocena M. The nucleoporin ALADIN regulates Aurora A localization to ensure robust mitotic spindle formation. Molecular biology of the cell. 26(19):3424-38. 2015.