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AKT3 antibody

Cat.#: 107950

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Product Information

  • Product Name
    AKT3 antibody
  • Documents
  • Description
    AKT3 Rabbit Polyclonal antibody. Positive IHC detected in human kidney tissue. Positive WB detected in MCF7 cells, HeLa cells, human brain tissue, K-562 cells, NIH/3T3 cells. Observed molecular weight by Western-blot: 60kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat,Zebrafish; other species not tested.
  • Alternative names
    AKT3 antibody; DKFZp434N0250 antibody; PKB GAMMA antibody; PKBG antibody; PRKBG antibody; Protein kinase Akt 3 antibody; Protein kinase B gamma antibody; RAC gamma antibody; RAC PK gamma antibody; STK 2 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of AKT3 recombinant protein (Accession Number: NM_001206729). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    MCF7 cells were subjected to SDS PAGE followed by western blot with Catalog No:107950(AKT3 antibody) at dilution of 1:500

    MCF7 cells were subjected to SDS PAGE followed by western blot with Catalog No:107950(AKT3 antibody) at dilution of 1:500

    Immunohistochemistry of paraffin-embedded human kidney tissue slide using Catalog No:107950(AKT3 Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human kidney tissue slide using Catalog No:107950(AKT3 Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human kidney tissue slide using Catalog No:107950(AKT3 Antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemistry of paraffin-embedded human kidney tissue slide using Catalog No:107950(AKT3 Antibody) at dilution of 1:50 (under 40x lens)

  • Background
    AKT3, also named as PKBG, is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. AKT3 is a key modulator of several tumors like melanoma, glioma and ovarian cancer. Active AKT3 increases progressively during melanoma tumor progression with highest levels present in advanced-stage metastatic melanomas.
  • References
    • Liu J, Huang W, Ren C. Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways. Scientific reports. 5:11614. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"