-
Product Name
Human AKT3 (GST Tag) recombinant protein
- Documents
-
Description
AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.
-
Protein name
RAC-gamma serine/threonine-protein kinase
-
Protein short names
PKB-GAMMA; AI851531; MPPH2; DKFZP434N0250; RAC-PK-GAMMA; AKT3; MPPH; D930002M15RIK; NMF350; PKBG; PRKBG; I851531; RAC-GAMMA; STK-2
-
Uniprot ID
Q9Y243
-
Gene Name
AKT3; PKBG
-
Source/Expression Host
Baculovirus-Insect Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the full length of human PKBG (NP_005456.1) (Met 1-Glu 479) was expressed with the GST tag at the N-terminus.
-
Protein Species
Human
-
Molecular weight
The recombinant human PKBG/GST chimera consists of 704 amino acids and predicts a molecular mass of 81 kDa which is also estimated by SDS-PAGE.
-
Purity
> 95 % as determined by SDS-PAGE
-
Activity
No Kinase Activity
-
Validations
Human AKT3 Protein (GST Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"