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Product Name
Acetylcholinesterase antibody
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Description
Acetylcholinesterase Rabbit Polyclonal antibody. Positive WB detected in mouse liver tissue, NIH/3T3 cells. Positive IHC detected in human liver tissue. Observed molecular weight by Western-blot: 66-72 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
Acetylcholinesterase antibody; ACHE antibody; ARACHE antibody; N ACHE antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Acetylcholinesterase recombinant protein (Accession Number: BC094752). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
mouse liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:107737(ACHE antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human liver tissue slide using Catalog No:107737(ACHE Antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human liver tissue slide using Catalog No:107737(ACHE Antibody) at dilution of 1:50 (under 40x lens)
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Background
The classical role of acetylcholinesterase (AChE) is to terminate cholinergic neurotransmission by rapid hydrolysis of the neurotransmitter acetylcholine (ACh) at cholinergic synapses and neuromuscular junctions(PMID:20054652). AChE activity is significantly lower in aspirates from squamous cell carcinomas and the molecular distribution of AChE in both bronchial cells and fluids consisted of amphiphilic monomers and dimers(PMID:18211261). It has 4 isoforms produced by alternative splicing.
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References
- Wu YY, Wang X, Tan L. Lithium attenuates scopolamine-induced memory deficits with inhibition of GSK-3β and preservation of postsynaptic components. Journal of Alzheimer's disease : JAD. 37(3):515-27. 2013.
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