2019-nCoV S1 Protein (Mammalian, C-6His)

Cat.#: 521006

Size:

Special Price 369.0 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    2019-nCoV S1 Protein (Mammalian, C-6His)
  • Documents
  • Description
    Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It is been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
  • Protein short names
    S1 protein; 2019-nCoV S1 protein; coronavirus S1 Protein; cov S1 Protein
  • Uniprot ID
    QHD43416.1
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    The target gene encoding Val16-Arg685 is expressed with a 6His tag at the C-terminus.
  • Protein Species
    Severe acute respiratory syndrome coronavirus 2
  • Molecular weight
    100-130kDa, reducing conditions
  • Purity
    Greater than 95% as determined by reducing SDS-PAGE.
  • Activity
    Measured by its binding ability in a functional ELISA. Immobilized human ACE2 protein (Fc tag) at 2 μg/mL (100 μL/well) can bind SARS-CoV-2/2019-nCoV Spike Protein (S1 Subunit, His tag), the EC50 of SARS-CoV-2/2019-nCoV Spike Protein (S1 Subunit, His tag) is 200-600 ng/mL.
  • Validations

    2019-nCoV S1 Protein (Mammalian, C-6His)

    2019-nCoV S1 Protein (Mammalian, C-6His)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"