ZO-1 antibody

ZO-1 antibody

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• Material Safety Data Sheets (MSDS)

ZO-1 Rabbit Polyclonal antibody. Positive IF detected in HUVEC cells.

ELISA, IF

Human; other species not tested.

DKFZp686M05161 antibody; Tight junction protein 1 antibody; Tight junction protein ZO 1 antibody; TJP1 antibody; ZO 1 antibody; ZO1 antibody; ZO-1 antibody; Zona OCcludens protein 1 antibody; Zonula OCcludens protein 1 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_003257). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Tight junction (or zonula occludens) form the continuous intercellular barrier between epithelial and endothelial cells, which is required to separate tissue spaces and regulate selective movement of solutes across the epithelium and endothelium (PMID: 20066090). ZO-1 (also known as TJP1) is a peripheral membrane phosphoprotein located on the cytoplasmic face and is expressed in tight junctions of both epithelial and endothelial cells (PMID: 3528172). It binds the transmembrane proteins occludin and the claudins linking them to cytoskeletal actin (PMID: 17418867). ZO-1 belongs to a family of multidomain proteins known as the membrane-associated guanylate kinase homologs (MAGUKs). It is a pivotal tight junction protein and may be involved in signalling mechanisms regulating cell proliferation and differentiation (PMID: 22782886).